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  • #STR24## wherein R-R.sup.5 are as defined above and X is agood leaving group such as Br or I, to yield the desired product followed by removal of protecting groups, is necessary, and, if desired, isolating the biologically more active isomer by chromatography, fractional crystallization, or by resolution withan appropriate, optically active acid or base and, if desired, preparing a salt of the des
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