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  • As shown in reaction scheme 6 compounds of formula XIV, in which Y3 is a suitable leaving group, such as e.g. iodine or bromine, and PG5 stands for a suitable temporary protective group for the carboxyl group, for example tert-butyl, can be reacted with boronic acids of formula R??????B(OH)2, in which R??? is the terminal aryl or heteroaryl moiety of the abovementioned Aa1 or Ha1 radicals, or the
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