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  • Stresses such as lack of growth factors, nutrient deprivation, or hypoxia inhibit mTOR, generating hypo-phosphorylated (active) forms of the 4E-BPs that sequester eIF4E, preventing eIF4F complex formation and blocking cap-dependent mRNA translation (Gingras et al., 1998). mTOR may also phosphorylate eIF4GI, possibly indirectly (Raught et al., 2000).
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