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  • Although PQ accumulation tended to be higher in other tissues such as brain, the differences did not reach statistical significance (data not shown).Figure 4PQ toxicokinetics in the mice of different Mate1 genotypes. (A) The plasma concentration profile of PQ in Mate1???/??? (???) and Mate1+/+ (???) mice. 50 mg/kg PQ in saline was administered via tail vein injection.
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