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  • The R substituent on the nitrogen (N???4) can be a hydrogen, a C1-8 alkyl group, an aryl group, or C(O)-YR27, wherein Y is sulfur or oxygen, or nitrogen and R27 is CH2OCH3, vinyl, a C1-9 straight chain alkyl, a C3-6 branched chain alkyl, a C3-8 cycloalkyl, polyethylene glycol, polysaccharide, or other polymer, a peptide, or a protein.
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