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  • At the 5'-and 3'-termini of the respectiveoligonucleotide derivative molecules, the free valency of the radicals of any of the above formulae I, I*, II to X and II* to X* is bonded preferably to hydrogen if the terminal atom is selected from N, O and S and to hydroxy or an analogue thereof, suchas halogen, for example Cl, Br or L, mercapto (SH) or azido (N.sub.3), if the terminal, atom is C, more
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