It remained mysterious that how many times the anatomically modern human migrated out of Africa, since that among the three superhaplogrous C, DE and F, Haplogroup F distributes in whole Eurasia, C in Asia and Austronesia, D exclusively in Asia, while D's brother clade E distribute mainly in Africa, so there are two hypotheses, 1) haplogroups D and CF migrated out of Africa separately; 2) the sing