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  • Representative examples of suitable methods for constructing alphavirus-based vector systems are described in more detail in PCT Publication No. WO 97/38087 entitled ???Recombinant Alphavirus-Based Vectors With Reduced Inhibition Of Cellular Macromolecular Synthesis??? and U.S. Pat. Nos. 5,091,309 and 5,217,879, 5,843,723, and 5,789,245.
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