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  • Typically, a therapeutically effective amount of a modified immunoglobulin in the form of an modified antibody or antibody fragment according to the invention is an amount such that when administered in physiologically tolerable composition is sufficient to achieve a plasma concentration of from about 0.01 microgram (??g) per milliliter (ml) to about 100 ??g/ml, preferably from about 1 ??g/ml to a
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