yl-CoA/CoA ratio and the pyruvate dehydrogenase complex (PDH) (Figure 1).5,6Figure 1L-carnitine and energy metabolism.Regulation by LC of the supply of energy is especially important in heart tissue.7 Moreover, cardiovascular diseases, such as heart failure and ischemia, are frequently accompanied by decreased myocardial ATP levels leading to lower mechanical work efficiency.8 Thus LC and its deri