By 12 months, signs and symptoms, such as skin changes and hair loss, begin to appear.Growth failure during the first year of lifeA narrowed face and beaked noseNarrow, shrunken or wrinkled faceAlopecia (baldness, loss of eyebrows and eyelashes)Scleroderma like skin conditionsDwarfism and mental retardationLarge head for size of face (macrocephaly)Small jaw (micrognathia)Nail and dental abnormalit