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  • Synergistic effects have been observed in animals administered a combination of rotenone and lipopolysacchide, a molecule that stimulates inflammation (Gao et al. 2003; Thiruchelvam et al. 2000b).Manganese and PD. Although manganese is an essential trace element, chronic occupational exposure to high levels of this metal causes accumulation in the basal ganglia, resulting in manganism, a condition
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