iphery of the glands Thus multifactorial diseases hallmarked by hyperprolifera-tion and inflammation such as acne are promising research a DP IV APN b 120fields for therapeutic applications of ectopeptidase inhibitors. 100 CD26 Our knowledge about the pathogenetic steps leading to 80 Countsacne initiation is still incomplete and subject of controversial 60 40discussion (Zouboulis et al., 2005).