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  • Preferably, 5%-50% organic solvents, including acetonitrile, dimethyl sulfoxide (DMSO), tetrahydofuran, acetone, dimethyl foramide (DMF), dioxane, isopropanol, ethanol, methanol, or the like, should be present in the reaction mixture to help solubilize the neotame ester and accelerate the hydrolysis.
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