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  • 1 isoform.In 3D Matrigel/collagen (50:50) cultures (Fig. 2 C, middle and bottom), Akt2 down-regulation suppressed the IGF-IR???induced hyperproliferative phenotype, resulting in structures that resembled parental MCF-10A acini, although slightly larger (Fig. 2 C, compare h with g and f).
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