None of the other factors, including education and sex, are significantly associated with CSF A??42 or affect the associations between A??42 and APOE2/APOE4 and age.The variation in both CSF tau and ptau181 levels is higher for individuals age 55 y or more compared with those age <55 y (for CSF tau, ??2(1)=9.01, p=.0027; for