Specifically, men under age 65 with a history of 40 or more pack-years" (those who smoke a pack a day for 40 years or two packs a day for 20 years) of cigarette smoking face a 100 percent increased risk - or double the risk - of developing more aggressive forms of the disease as compared to nonsmokers, according to senior author Janet L. Stanford, Ph.D., and colleagues in Fred Hutchinson's Public