Vomiting (vomiting more than 4-5 times in a 24 hour period) Diarrhea (4-6 episodes in a 24-hour period) Unusual bleeding or bruising Black or tarry stools, or blood in your stools or urine Extreme fatigue (unable to carry on self-care activities) Mouth sores (painful redness, swelling or ulcers) Yellowing of the skin or eyes.Signs of infection such as redness or swelling, pain