A pharmaceutical composition comprising a pharmaceutically acceptable carrier, diluent or excipient and a compound having the formula ##STR13## where X is a bond or --CH2 --;R2 is a heterocyclic ring selected from pyrrolidino; R is OH, --OSO2 --(CH2)n --CH3 or ##STR14## R1 is hydrogen, OH, fluoro, chloro, --OSO2 --(CH2)n --CH3, or ##STR15## each R3 is independently C1 -C6 alkyl, C3 -C6 cycloalkyl,