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  • Specifically, the Board noted that the FDA ???recognized that there was a need to eliminate impurities in oxycodone,??? and then proceeded to walk through the prior art, which disclosed: that both 14-hydroxy and 8,14-dihydroxy were known impurities during the thebaine oxidation reaction; that treatment of 8,14-dihydroxy with hydrochloric acid converts 8,14- dihydroxy into 14-hydroxy under certain
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