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| - plicating DNA sequences can be introduced into cells to provide production of the desired polypeptide for periods of up to six months. [0961] The polynucleotide construct can be delivered to the interstitial space of tissues within the an animal, including of muscle, skin, brain, lung, liver, spleen, bone marrow, thymus, heart, lymph, blood, bone, cartilage, pancreas, kidney, gall bladder, stomach
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