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  • This reaction yields the lipid-DTB-drug conjugate illustrated in FIG. 2A. The conjugate, upon exposure to reducing conditions, i.e., a reducing agent such as cysteine or glutathione, decomposes to yield the products shown in FIG. 2B. As shown, thiolytic cleavage of the conjugate results in regeneration of the drug in an unmodified, natural state.
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