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  • The acylating species of formula (20) is then used to acylate a tricyclic benzodiazepine of formula (1) to yield the desired compound of formula (I), wherein A, B, D, E, G, X, Y, and R4 are as defined above, R2 is hydrogen, and R1 is a heterocyclic moiety selected from the (f) group of heterocycles defined above.
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