For example, using the methods we describe here (and particularly findings i) and iii) above), implemented in the software package BIMBAM, analysing the whole of chromosome 22, in 675 individuals, with E = 5 and K = 10 takes just under an hour on a single Mac PRO desktop computer (with 3.0 GHz CPU and 8G memory, although memory used for simulations here was less than 1G).