with the proviso that when Z is a bond or C1-5 alkylene then R??? is other than ???O???C1-3 alkylene-S(O)2-alkyl, and with the further proviso that when Z is a bond or C1-5 alkylene and R2 is ???X???Y???R4 and Y is ???N(R8)-Q-, then Q is other than ???C(R6)???N(R8)???W???;