In this regard, resolvin E1 (RvE1) has shown benefit in preclinical models or clinical trials of a number of chronic inflammatory diseases, including asthma, rheumatoid arthritis, atherosclerosis, and obesity-related adipose inflammation (www.resolvyx.com) (67), and neuroprotectin D1 protected human neurons from beta-amyloid???induced inflammation and cell death in vitro (68).