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| - Signs and symptoms of PAA neurotoxicity, including somnolence, fatigue, lightheadedness, headache, dysgeusia, hypoacusis, disorientation, impaired memory, and exacerbation of preexisting neuropathy, were observed at plasma PAA concentrations ???500 ??g/mL in a study of cancer patients who were administered IV PAA. In this study, adverse events were reversible.
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