Data from our and other groups have also shown the ability of lipid-raft localized CFTR to modulate NF??B mediated inflammatory signaling and innate immune response (Dudez et al., 2008; Grassme et al., 2008; Kowalski and Pier, 2004; Reiniger et al., 2007; Schroeder et al., 2002; Vij et al., 2009).