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  • First, proximal muscle weakness is a prominent feature of the clinical syndrome of vitamin D deficiency,11,12 and muscle weakness is a major risk factor for falls in older persons.13 Second, highly specific receptors for 1,25-dihydroxyvitamin D are expressed in human muscle tissue,11,14 decline with age,15 and promote protein synthesis.14,16 Third, a vitamin D receptor???dependent action of vitami
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