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  • First, compounds XI, wherein E is a suitable leaving group, are reacted with compounds XII, wherein R1 and R2 are as defined above and R8 is H, (C1-C6)alkyl or (C6)aryl, providing compounds XIII. Suitable leaving groups are well known in the art, for example, but not limited to halides, such as chloride, bromide, and iodide; aryl- or alkyl-sulfonyloxy, substituted arylsulfonyloxy (e.g., tosyloxy o
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