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  • File:Caffeine metabolites.svg Caffeine from coffee or other beverages is absorbed by the stomach and small intestine within 1 hour of ingestion and then distributed throughout all tissues of the body.[4] It is eliminated by first-order kinetics.[5] Caffeine can also be ingested rectally, evidenced by the formulation of suppositories of ergotamine tartrate and caffeine (for the relief of migraine)[
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