Vitamin E is a powerful antioxidant, and hence an obvious choice once the role of oxidant stress was made clear in NAFLD.17 We had known since at least 1992 that people with fatty liver disease and NASH had depressed levels of vitamin E in their blood, the result of that increased oxidation.18,19 By the beginning of this century, relatively low-dose vitamin E (450 IU/day) was shown to reduce circu