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  • LMP1 is a CD40 mimic, which upregulates cellular Bcl-2, A20, and other proteins that inhibit apoptosis and LMP1 activates the NF-??B signaling pathway to simulate cell growth.Therapeutic options for EBV-associated PTLD and non-Hodgkin???s lymphoma (NHL)Treatment strategies for EBV-associated PTLD include reduction of immunosuppression, which is often successful in SOT, use of anti-B-cell monoclona
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