Liver toxicity of INH treatment derives from INH itself (a hydrazine derivative) and its metabolites, including acetyl-hydrazine, hydrazine and ammonia, and is thought to involve the formation of reactive oxygen species that can cause necrosis and autoimmunity [Articles:21412230, 17995946, 18544910, 18220565, 1149365] and may also involve epigenetic effects [Article:17156885].Due to reduced metabo