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  • In such conditions, NSAIDs are used chronically, and the affected patients frequently have co-morbidities such as hypertension, diabetes and obesity, as well as often also taking glucocorticoids or anti-coagulants.By inhibiting the activity of cyclo-oxygenase (COX), NSAIDs prevent the formation of prostaglandin (PG) H2, which is the precursor for the production of all other PG and thromboxane subt
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