In another specific embodiment of the invention, an antibody is provided as described herein, particularly a monoclonal antibody including any functionally equivalent antibody or functional parts thereof, which antibody binds to A?? monomeric peptide 1-40 particularly to A?? monomeric peptide 1-40 and to soluble polymeric and/or oligomeric amyloid peptide comprising a plurality of A??1-42 monomeri