In one embodiment, an antibody is provided, particularly a monoclonal antibody according to the invention including any functionally equivalent antibody or functional parts thereof, which antibody binds preferentially to A??1-40 monomeric peptide and also to A??1-42, oligomeric and/or polymeric peptides, but shows a substantially weaker binding to A?? monomeric peptide 1-28 and/or an intermediated