In fulfillment of the above and other objects, this invention provides a method of inhibiting angiogenesis which comprises administering to a mammal in need of treatment an angiogenesis inhibiting dose of a compound of the formula ##STR1## wherein R and R1 are individually H or CH2 R4, except that at least one of R and R1 must be other than H, wherein R4 is H, (C1 -C21)alkyl-R5, (C2 -C12)alkenyl,