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  • In certain embodiments, one of Q1 and Q2 is H for essentially each bicyclic nucleoside having Formula III. In certain embodiments, one of Q1 and Q2 is H and the other one of Q1 and Q2 is substituted C1-C6 alkyl for essentially each bicyclic nucleoside having Formula III. In certain embodiments, one of Q1 and Q2 is H and other one of Q1 and Q2 is CH2F, CHF2 or CF3 for essentially each bicyclic nucl
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