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  • Interestingly, comorbid substance use was an effect modifier; respondents with a comorbid substance use disorder (for example, alcohol, marijuana, amphetamines, opioids, sedatives, tranquilizers, cocaine, inhalants, hallucinogens, heroin, and other drugs) and AD demonstrated an increased risk of daily smoking onset (OR 2.22 (1.01 to 4.91)), whereas those without comorbid substance use disorder had
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