Interestingly, we have recently reported that the CBD-mediated direct inhibition of human CYP1A1 activity is the strongest among those of CYP activities reported so far.8) In addition, CYP1A1 was more potently inhibited by CBD than by the other major phytocannabinoids examined.8)CYP1A1 is expressed in various tissues including the liver and lung,14???16) although the constitutive expression level