In addition, NK cell-derived chemokines and cytokines, most notably IFN-??, can exert potent regulatory effects on targets cells, as well as recruit and activate other cells of the immune system, including macrophages and dendritic cells, and T and B lymphocytes, which mediate further anti-viral and anti-tumor immunity (35, 36).In addition to cytotoxicity and cytokine secretion, certain stimuli (e