In theory, pairwise combinations of alleles at different loci can differ in parameters such as magnitude, significance and patterns of LD. This has been confirmed empirically in the characterization of interallelic LD between pairs of dinucleotide repeat loci spanning human chromosome 11p15 [2], and in the analysis of LD between the TH01 microsatellite and IGF2 SNP haplotypes in the context of the