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  • In one embodiment, the invention features chemically-modified siNA constructs that mediate RNAi against a VEGF and/or VEGFR target polynucleotide in a cell, wherein the chemical modifications do not significantly effect the interaction of siNA with a VEGF and/or VEGFR target RNA molecule, DNA molecule and/or proteins or other factors that are essential for RNAi in a manner that would decrease the
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