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  • In addition, gene targeting studies from our lab and other groups demonstrated that HA, H1R, H2R, H3R, and H4R play important roles in EAE susceptibility and pathogenesis, either by regulating encephalitogenic T-cell responses, cytokine production by antigen-presenting cells (APCs), BBB permeability, or T regulatory (Treg)-cell activity [27, 30???34].The current therapeutic mainstays for MS includ
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