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  • JNK and p38 MAPKs are predominantly activated not only by stress such as osmotic changes and heat shock but also by inflammatory cytokines TNF-?? and IL-1?? and bacterial lipopolysaccharide (LPS) [23???25].Several studies show that MAPKs are actively repressed and cannot be activated when Leishmania-infected macrophages are stimulated with a variety of agonists.
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