R1 Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln R2???(SEQ ID NO:1), wherein R1 is absent or is an amino terminal capping group and R1 is absent or is a carboxy terminal capping group of the peptide compound and wherein the peptide compound upregulates expression of a gene encoding an antioxidative enzyme.