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  • Excitotoxicity due to excessive glutamate release and impaired uptake occurs as part of the ischemic cascade and is associated with stroke,[4] autism[citation needed], some forms of intellectual disability, and diseases such as amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease.[4][17] In contrast, decreased glutamate release is observed under conditions of classical phenylketonuria
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