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  • Demethylation of intermediate 10 with aluminum chloride in t-butyl mercaptan and subsequent ether formation by reaction of the 5-hydroxyindole intermediate with QX where X is a leaving group such as halogen or mesylate and Q is selected from alkyl, optionally substituted aryl or arylalkyl, and optionally substituted heteroaryl or heteroarylalkyl, provides the intermediate indole 11.
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