ro-inflammatory genes [20,41,52]Upregulates the production of pro-inflammatory cytokines and chemokines such as IL-8 and RANTES [20,41,52]ORF3b Upregulates cytokines and chemokines by modulating the transcriptional activity of RUNX1b [73]AP1 transcriptional activity through activation of JNK and ERK pathways [74] ORF6 Induces DNA synthesis [82]Suppresses the induction of type 1 IFN and IFN signali